Investigator Argus X-12 QS Kit

 Investigator Argus X-12 QS Kit

Ref. 383223

For multiplex amplification of 12 X-chromosomal STRs, D21S11 and Amelogenin, with an innovative Quality Sensor

  • Co-amplification of 12 X-chromosomal and one autosomal alignment marker to avoid sample mix-up
  • Integrated Quality Sensor for better decision making and data interpretation
  • PCR run speed of around 80 minutes for faster results
  • Smart primer design with reduced allelic overlap for unambiguous results
  • High sensitivity and inhibitor resistance

The Investigator Argus X-12 QS Kit is a multiplex solution for human identification. The 12 X-chromosomal markers, D21S11 and Amelogenin are co-amplified. The autosomal marker, D21S11, enables alignment of the Investigator Argus X-12 QS Kit profile with a profile from any other autosomal STR kit from the expanded CODIS or ESS market, to minimize the risk of sample mix-ups. With its innovative Quality Sensor (QS), the Investigator Argus X-12 QS Kit includes a novel internal performance control. This allows you to readily determine if your PCR run was successful or if there was no DNA present in your sample. The kit utilizes QIAGEN’s fast-cycling technology, enabling amplification in just ~80 minutes. Highly sensitive, with rapid and reliable results from trace or reference DNA, the Investigator Argus X-12 QS Kit is suitable for paternity or kinship testing and for gonosomal STR analysis of forensic stains.

Principle

The Investigator Argus X-12 QS Kit uses QIAGEN’s fast-cycling PCR technology for the direct, simultaneous amplification of 12 X-chromosomal markers, D21S11 and Amelogenin. The amplification of the 12 X-chromosomal markers (see Table 1 and 2), with heightened discrimination power, meets the needs for complex kinship and paternity testing and helps fulfill the demands of complicated deficiency cases involving at least one female. The 12 X-chromosomal markers are clustered into four linkage groups (three markers per group; Table 1), and thus each set of three markers is handled as a haplotype for genotyping.
Argus X-12 QS Kit principle
Applications
The Investigator Argus X-12 QS Kit enables simultaneous amplification of 12 X-chromosomal markers, and is highly suitable for:

  • Kinship and paternity testing, especially deficiency cases
  • Population genetics and anthropological studies
  • Analysis of stains with female traces on a male background